Publications

*Lab members are shown in bold.

2024

Glioma subtype classification from histopathological images using in-domain and out-of-domain transfer learning: An experimental study.

Despotovic V, Kim SY, Hau AC, Kakoichankava A, Klamminger GG, Borgmann FBK, Frauenknecht KBM, Mittelbronn M, Nazarov PV.

Heliyon. 10(5):e27515.

The neuronal transcription factor MEIS2 is a calpain-2 protease target.

Müller T, Reichlmeir M, Hau AC, Wittig I, Schulte D.

J Cell Sci. 137(4):jcs261482.

The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen.

Malta TM, Sabedot TS, Morosini NS, Datta I, Garofano L, Vallentgoed W, Varn FS, Aldape K, D'Angelo F, Bakas S, Barnholtz-Sloan JS, Gan HK, Hasanain M, Hau AC, Johnson KC, Cazacu S, deCarvalho AC, Khasraw M, Kocakavuk E, Kouwenhoven MCM, Migliozzi S, Niclou SP, Niers JM, Ormond DR, Paek SH, Reifenberger G, Sillevis Smitt PA, Smits M, Stead LF, van den Bent MJ, Van Meir EG, Walenkamp A, Weiss T, Weller M, Westerman BA, Ylstra B, Wesseling P, Lasorella A, French PJ, Poisson LM; The GLASS Consortium; Verhaak RGW, Iavarone A, Noushmehr H.

Cancer Res. 84(5):741-756.

2023

Actin cytoskeleton depolymerization increases matrix metalloproteinase gene expression in breast cancer cells by promoting translocation of cysteine-rich protein 2 to the nucleus.

Mgrditchian T, Brown-Clay J, Hoffmann C, Müller T, Filali L, Ockfen E, Mao X, Moreau F, Casellas CP, Kaoma T, Mittelbronn M, Thomas C.

Front Cell Dev Biol. 11:1100938.

Prediction and verification of glycosyltransferase activity by bioinformatics analysis and protein engineering.

Gerloff DL, Ilina EI, Cialini C, Mata Salcedo U, Mittelbronn M, Müller T.

STAR Protoc. 4(1):101905.

2022

Federated learning enables big data for rare cancer boundary detection.

Pati S, Baid U, Edwards B, Sheller M, Wang SH, Reina GA, Foley P, Gruzdev A, Karkada D, Davatzikos C, Sako C, Ghodasara S, Bilello M, Mohan S, Vollmuth P, Brugnara G, Preetha CJ, Sahm F, Maier-Hein K, Zenk M, Bendszus M, Wick W, Calabrese E, Rudie J, Villanueva-Meyer J, … Hau AC, ... Menze B, Barnholtz-Sloan JS , Martin J , Bakas S.

Nat Commun. 13(1):7346.

Glioma progression is shaped by genetic evolution and microenvironment interactions.

Varn FS, Johnson KC, Martinek J, Huse JT, Nasrallah MP, Wesseling P, Cooper LAD, Malta TM, Wade TE, Sabedot TS, Brat D, Gould PV, Wöehrer A, Aldape K, Ismail A, Sivajothi SK, Barthel FP, Kim H, Kocakavuk E, Ahmed N, White K, Datta I, Moon HE, Pollock S, Goldfarb C, Lee GH, Garofano L, Anderson KJ, Nehar-Belaid D, Barnholtz-Sloan JS, Bakas S, Byrne AT, D'Angelo F, Gan HK, Khasraw M, Migliozzi S, Ormond DR, Paek SH, Van Meir EG, Walenkamp AME, Watts C, Weiss T, Weller M, Palucka K, Stead LF, Poisson LM, Noushmehr H, Iavarone A, Verhaak RGW; The GLASS Consortium.

Cell. 185(12):2184-2199.e16.

Enzymatic activity of glycosyltransferase GLT8D1 promotes human glioblastoma cell migration.

Ilina EI, Cialini C, Gerloff DL, Duarte Garcia-Escudero M, Jeanty C, Thézénas ML, Lesur A, Puard V, Bernardin F, Moter A, Schuster A, Dieterle M, Golebiewska A, Gérardy JJ, Dittmar G, Niclou SP, Müller T, Mittelbronn M.

iScience. 25(2):103842.

The multiple roles of actin-binding proteins at invadopodia.

Mgrditchian T, Sakalauskaite G, Müller T, Hoffmann C, Thomas C.

Int Rev Cell Mol Biol. 360:99-132.

Transcriptional cooperation of PBX1 and PAX6 in adult neural progenitor cells.

Hau AC*, Mommaerts E, Laub V, Müller T, Dittmar G, Schulte D.*

Sci Rep. 11(1):21013. *co-corresponding author

Cystathionine-γ-lyase drives antioxidant defense in cysteine-restricted IDH1-mutant astrocytomas.

Cano-Galiano A, Oudin A, Fack F, Allega MF, Sumpton D, Martinez-Garcia E, Dittmar G, Hau AC, De Falco A, Herold-Mende C, Bjerkvig R, Meiser J, Tardito S, Niclou SP.

Neurooncol Adv. 3(1):vdab057.

Protocol for derivation of organoids and patient-derived orthotopic xenografts from glioma patient tumors.

Oudin A, Baus V, Barthelemy V, Fabian C, Klein E, Dieterle M, Wantz M, Hau AC, Dording C, Bernard A, Michelucci A, Yabo YA, Kanli G, Keunen O, Bjerkvig R, Niclou SP, Golebiewska A.

STAR Protoc. 2(2):100534.

2021

2020

Glioblastoma Organoids: Pre-Clinical Applications and Challenges in the Context of Immunotherapy.

Klein E, Hau AC, Oudin A, Golebiewska A, Niclou SP.

Front Oncol. 10:604121.

AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion.

Schuster A, Klein E, Neirinckx V, Knudsen AM, Fabian C, Hau AC, Dieterle M, Oudin A, Nazarov PV, Golebiewska A, Muller A, Perez-Hernandez D, Rodius S, Dittmar G, Bjerkvig R, Herold-Mende C, Klink B, Kristensen BW, Niclou SP.

Nat Commun. 11(1):6366.

Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology.

Golebiewska A*, Hau AC*, Oudin A*, Stieber D, Yabo YA, Baus V, Barthelemy V, Klein E, Bougnaud S, Keunen O, Wantz M, Michelucci A, Neirinckx V, Muller A, Kaoma T, Nazarov PV, Azuaje F, De Falco A, Flies B, Richart L, Poovathingal S, Arns T, Grzyb K, Mock A, Herold-Mende C, Steino A, Brown D, May P, Miletic H, Malta TM, Noushmehr H, Kwon YJ, Jahn W, Klink B, Tanner G, Stead LF, Mittelbronn M, Skupin A, Hertel F, Bjerkvig R, Niclou SP.

Acta Neuropathol. 140(6):919-949. *co-first